After you exceed around 2.14 billion in the score for the endless hard level, the score becomes negative, so new points make the number increase toward zero. I made it to level 248 or so with a score that should have been close to 5 billion, but I guess the score doesn't count once you reach this glitch. This is the max score on the leader boards, so it looks like others have encountered it as well.
I hope this bug is fixed, as I think it is a bit lame to play for 5 hours and not have your score recorded at all, let alone an awesome one.
Props to dave for an awesome game.
You should follow me on twitter here!
This was already reported. See the "score overflow" thread.